Regenerative medicine is a medical subspecialty that seeks to recruit and enhance the body's inherent healing armamentarium in the treatment of patient pathology. This therapy intends to assist in the repair and potentially replace or restore damaged tissue through the use of autologous or allogenic biologics. This field is rising like a Phoenix from the ashes of underperforming conventional therapy amidst the hopes and high expectations of patients and medical personnel alike.

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Several cell-based therapies have been proposed in recent years for the management of low back pain, including the injection of medicinal signaling cells or mesenchymal stem cells and platelet-rich plasma.

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Regenerative injection-based therapy has established itself as a therapeutic option for the management of a variety of painful musculoskeletal conditions. This work aimed to review the current literature regarding regenerative injection therapy for axial/radicular spine pain.